Instrumentos de laboratorio
Today I attended the seminar “The Human Brain, Development and Structure” (El Cerebro Humano, Desarrollo y Estructura) presented by Professor Emeritus Dr. Miguel Marín-Padilla (Department of Pathology, Dartmouth Medical School, Hanover NH, USA) here at Vall d’Hebron Hospital (Neuroscience Seminars). Sincerely, it was probably the most pleasant seminar of the last year. Miguel is able to teach that science is not necessarily joined to complex and expensive techniques. He encourage young researchers to use their minds and innovate. Difficult words nowadays when science has become a pseudo-industrial activity.
One thing is clear. Real skillful scientists are modest.
Jennifer Pérez Boza has got a grant from the Instituto Carlos III (FIS, Fondo de Investigaciones Sanitarias).
Dr. Manuel Comabella and Dr. Xavier Montalban from our research group have contributed to the study “Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis” published in Nature this month (Nature 476, 214–219). This is probably the largest genetics study ever undertaken on Multiple Sclerosis and includes contributions from almost 250 researchers as members of the International Multiple Sclerosis Genetics Consortium and the Wellcome Trust Case Control Consortium.
Next Wednesday, Dr. Martin Indarte will make a presentation in our lab with the title: Computer assisted drug discovery: What can it do for your research?
He is working at the Laboratory of Biologia Computacional i Proteòmica, Institut de Biotecnologia i Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB), directed by Dr. Xavier Daura.
Abstract of the presentation:
“Drug discovery and development are extremely time and resources consuming processes. Computational approaches offer an inexpensive and interesting approach that can expedite drug discovery, design, development and optimization of lead compounds. Commonly used computational approaches include ligand-based drug design (e.g. pharmacophore searches), structure-based drug design (docking), homology modeling and quantitative structure-activity and quantitative structure-property relationships (QSAR/QSPR). These approaches can also guide site directed mutagenesis, shed some light on protein behavior, peptide binding and molecular recognition phenomena. In this talk, several first hand examples of successful interactions between molecular modeling, molecular biology and pharmacology will be covered with the aim of improving positive interactions between experimentalists and molecular modelers. If you ever wondered what is all the fuzz about molecular modelers and how they could help your research, this talk is for you.”
We have obtained 20,000 additional hours for the TNF project at BSC.
“The application of high-throughput technologies in medical genomics yields complex, multidimensional data sets that describe in detail the myriad changes that occur within individual cells and how these changes differ between patients, cells or conditions. Usually we want to use this data to answer some specific questions. For instance, which of the long list of mutations detected are likely to affect the function of the protein and which are probably neutral? Which of the genes affected by those mutations are already known to be involved in cancer or other diseases? Which pathways or biological processes are affected by the transcriptomic alterations detected in my experiment? Etc.
We need to apply bioinformatic approaches to answer these questions. This course provides theoretical and practical expertise in the field of bioinformatics for integrative genomics. Students are updated on the state of the art in the field and they become capable of handling and analyzing genomics data. Upon completion, the attendees are able to perform integrative analysis and interpret the results, in order to answer specific biological questions.
To achieve these objectives we will use three tools developed in our lab:”
Today, Dr. Luis F. Santamaría-Babi, researcher at Institute for Research in Biomedicine (IRB Barcelona) in the “Gene Expression Group”, gave as an interesting seminar on “Lymphocyte homing”.
CESCA (at present ‘Center for Scientific and Academic Services of Catalonia’; before known as the ‘Supercomputing Centre of Catalonia Consortium’) has accepted our new project on TNF signaling. This will provide us with 200,000 computational hours along this year.